POS0988 ANKYLOSING SPONDYLITIS (AS) ACTIVITY DURING THE YEAR AFTER CHILDBIRTH.

Background Currently, data on the course of AS during pregnancy are being accumulated. However, information about activity in postpartum period including against background lactation, remains scanty and contradictory. Objectives To assess dynamics year after childbirth, to identify predictors high activity. Methods 44 women with confirmed (modified New York criteria, 1984) were followed within 1 childbirth. The visits carried out 1, 6 12 months delivery. average age patients was 32,5 ± 5,8 years, duration disease 149,0 96,3 months. according Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) 1st, 2nd 3rd trimesters 2,8 1,9; 2,9 1,9 2,7 1,8, respectively. Score CRP (ASDAS-CRP) 1,8 [1,6; 2,5]; 2,1 [1,5; 2,9] 2 [1; 3,5], Delivery 39,0 1,2 weeks. Lactation established 40 10 [4; 12] Results Subjective deterioration well-being noted by 36 (81,8%) 8 17] weeks delivery, while 29 (65,9%) associated increased AS, recurrence uveitis arthritis, 7 cases severity back pain mechanical rhythm revealed. month 39 (88,6%) reported NRS intensity 3,0 [2,0; 6,0]; night – 6,0]. observed 38 (86,4%) patients, its 4,0 [3,0; 5,0]; nocturnal 32 5,0]. 33 (75%) experienced Night 27 2,0 [1,0; 4,0]. BASDAI at giving birth was: 2,4 [1,4; 4,2]; 2,6 4,4]; 4,1], respectively (p > 0,05). ASDAS-CRP [1,2; 2,7]; 1,7 [1,3; 2,3], level 3,4 8,6], 3,5 7,8] [0,8; 8,2] mg/l, >0,05). There no differences between childbirth pregnancy. values BASDAI, ASDAS-CRP, CRP, without lactation. Predictors (BASDAI ≥ 4) delivery were: 4 1st trimester (OR 8,1; 95% CI 37,0; p = 0,006) 5,1; 20,6; 0,02); 4,3; 1,1 17,2; 0,04); cancellation bDMARD therapy 21,0; 1,0 440,9; 6,5; 1,5 28,7; 0,01), 6,7; 1,6 27,8; 0,009) 8,7; 38,6; 0,005); 4,0; 15,9; < predictor 8,3; 37,2; 0,005). Conclusion increase ASDASCRP 66% a subjective symptoms intensification. High risk factor for Given generally accepted opinion that time conception is gestation, we can talk importance planning from point view period. Further studies large groups required clarify Disclosure Interests None declared